2-substituted piperazines as constrained amino acids. Application to the synthesis of potent, non carboxylic acid inhibitors of farnesyltransferase

MeSH terms

• Alkyl and Aryl Transferases*
• Animals
• Antineoplastic Agents / chemical synthesis*
• Antineoplastic Agents / pharmacology
• Cell Death / drug effects
• Cell Division / drug effects
• Cell Line, Transformed
• Enzyme Inhibitors / chemical synthesis*
• Enzyme Inhibitors / chemistry
• Enzyme Inhibitors / pharmacology
• Farnesyltranstransferase
• Mice
• Mice, Nude
• Molecular Conformation
• Molecular Structure
• Neoplasm Transplantation
• Piperazines / chemical synthesis*
• Piperazines / pharmacology*
• Polyisoprenyl Phosphates / metabolism
• Protein Prenylation
• Protein Processing, Post-Translational / drug effects
• Rats
• Sarcoma, Experimental / drug therapy
• Sarcoma, Experimental / pathology
• Sesquiterpenes
• Transferases / antagonists & inhibitors*
• ras Proteins / metabolism